<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:316eb9bf-eb12-40d1-909c-2d6fa4ebf1cf,g:49ad4c01-2558-485d-a84f-a89fdd6d14fb-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://mimedx.com/role/CoverPageDocument" xlink:type="simple" xlink:href="mdxg-20230613.xsd#CoverPageDocument"/>
  <link:presentationLink xlink:role="http://mimedx.com/role/CoverPageDocument" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_e493d3d4-b718-4f33-9826-e759ec6efc02" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_DocumentType_e493d3d4-b718-4f33-9826-e759ec6efc02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_d9ccbe09-3148-43e4-90e7-5667a55ffdcf" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_DocumentPeriodEndDate_d9ccbe09-3148-43e4-90e7-5667a55ffdcf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_711c3430-349a-4d81-b23a-d1a9ca6bd2e1" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_EntityRegistrantName_711c3430-349a-4d81-b23a-d1a9ca6bd2e1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_b13ebbac-599b-4e75-a025-f0917dfdf90e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_EntityIncorporationStateCountryCode_b13ebbac-599b-4e75-a025-f0917dfdf90e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_4a4a83ea-02dc-4290-aee9-b8c75c279939" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_EntityFileNumber_4a4a83ea-02dc-4290-aee9-b8c75c279939" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_99ede8b8-d00c-4f35-b611-33f2367ca48a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_EntityTaxIdentificationNumber_99ede8b8-d00c-4f35-b611-33f2367ca48a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_749c2dd0-e3c3-4be2-a2ed-206c0cedc4be" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_EntityAddressAddressLine1_749c2dd0-e3c3-4be2-a2ed-206c0cedc4be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_92faa0d1-f277-41e8-9427-52e3f85501f0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_EntityAddressCityOrTown_92faa0d1-f277-41e8-9427-52e3f85501f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_910a7ecb-1655-4edd-bac0-341e65322dfd" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_EntityAddressStateOrProvince_910a7ecb-1655-4edd-bac0-341e65322dfd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_0cdfc12e-c464-415b-81d0-df3da3c5759b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_EntityAddressPostalZipCode_0cdfc12e-c464-415b-81d0-df3da3c5759b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_e3709d8c-5843-43bc-9d68-4718957ed2fa" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_CityAreaCode_e3709d8c-5843-43bc-9d68-4718957ed2fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_4e79c895-3e50-48f0-a428-79483016eba9" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_LocalPhoneNumber_4e79c895-3e50-48f0-a428-79483016eba9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_cc71fed3-3edd-440a-b38d-69506782aeae" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_WrittenCommunications_cc71fed3-3edd-440a-b38d-69506782aeae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_ce9f0ba0-5c97-4ab6-91d6-913198c16732" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_SolicitingMaterial_ce9f0ba0-5c97-4ab6-91d6-913198c16732" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_6ef43197-1256-47d9-8953-d68a0ecc4827" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_PreCommencementTenderOffer_6ef43197-1256-47d9-8953-d68a0ecc4827" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_e9bbc22f-619d-449c-bb2a-8d3bb1bb0f2a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_e9bbc22f-619d-449c-bb2a-8d3bb1bb0f2a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_ea5914e5-34be-4c42-84d6-4254922c54cf" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_Security12bTitle_ea5914e5-34be-4c42-84d6-4254922c54cf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_3a6cff87-9883-446c-ab23-61ccdc1cbb68" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_TradingSymbol_3a6cff87-9883-446c-ab23-61ccdc1cbb68" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_05534ea0-f727-400d-bf37-1d4cb1c8d30f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_SecurityExchangeName_05534ea0-f727-400d-bf37-1d4cb1c8d30f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_0545c0da-6225-4ff9-823a-d70038494d82" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_EntityEmergingGrowthCompany_0545c0da-6225-4ff9-823a-d70038494d82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_c9364445-d9bc-4742-b770-dcde968d9a5e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_EntityCentralIndexKey_c9364445-d9bc-4742-b770-dcde968d9a5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_7e0ebf56-b12e-4100-9310-582733aa2e2a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_AmendmentFlag_7e0ebf56-b12e-4100-9310-582733aa2e2a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_b3d411d4-1f7d-435f-8e7a-c50f420b81bf" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_06a5abb4-ac05-4046-b7aa-956160e7efa4" xlink:to="loc_dei_CurrentFiscalYearEndDate_b3d411d4-1f7d-435f-8e7a-c50f420b81bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
